Chromosomes: Organization and function: Sumner, Adrian T.
نویسندگان
چکیده
منابع مشابه
The organization and function of chromosomes.
Introduction At the end of the summer of 2005, around 60 scientists came together in Rome to discuss various aspects of eukaryotic chromosome biology, including telomeres, centromeres, origins of replication, genome evolution and nuclear organization. Each of these topics is a well-established field with its own specialist meetings and, for the workshop’s participants, this was an unusual and w...
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Chromosomes are not distributed randomly in nuclei. Appropriate positioning can activate (or repress) genes by bringing them closer to active (or inactive) compartments like euchromatin (or heterochromatin), and this is usually assumed to be driven by specific local forces (e.g., involving H bonds between nucleosomes or between nucleosomes and the lamina). Using Monte Carlo simulations, we demo...
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Bacterial chromosomes are organized in stereotypical patterns that are faithfully and robustly regenerated in daughter cells. Two distinct spatial patterns were described almost a decade ago in our most tractable model organisms. In recent years, analysis of chromosome organization in a larger and more diverse set of bacteria and a deeper characterization of chromosome dynamics in the original ...
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Although the design of the synthetic yeast genome Sc2.0 is highly conservative with respect to gene content, the deletion of several classes of repeated sequences and the introduction of thousands of designer changes may affect genome organization and potentially alter cellular functions. We report here the Hi-C-determined three-dimensional (3D) conformations of Sc2.0 chromosomes. The absence o...
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ژورنال
عنوان ژورنال: Biochemistry and Molecular Biology Education
سال: 2004
ISSN: 1470-8175,1539-3429
DOI: 10.1002/bmb.2004.494032039998